In Vivo siRNA Resource

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Ambion Resources

An Introduction to RNAi In Vivo: Performing RNAi Experiments in Animals

In Vivo siRNA Reference List [Excel]
In vivo siRNA delivery and dosing strategies from the literature

Protocols
Basic information for local and systemic delivery of siRNAs into rodents

siRNA Database
Find Pre-designed and Validated siRNAs to mouse and rat genes

RNAi Resource
General information on RNAi (use of cultured cells)

Ambion Products

Silencer® In Vivo Ready siRNAs
Ready for formulation or direct injection into animals

Silencer® Pre-designed siRNAs
Guaranteed-to-silence siRNAs to essentially all human, mouse, and rat genes

Custom siRNA Synthesis
Premium quality siRNA synthesized to your specifications

pSilencer™ adeno 1.0-CMV System
Combines the advantages of adenoviral vectors with an efficient siRNA expression system

Articles of Note

Medarova Z, Pham W, Farrar C, Petkova V, Moore A. In vivo imaging of siRNA delivery and silencing in tumors. Nat Med. 2007 Mar;13(3):372-377. Epub 2007 Feb 25. [Abstract]
Describes the creation and use of siRNA-directed probes for in vivo tracking of tumor uptake by MRI and optical imaging in two separate tumor models.

In Vivo siRNA in the News

The RNA Drug Revolution—A New Approach to Gene Therapy 1/23/08

RNA Interference Therapy Heals Growth Deficiency Disorder in a Live Animal 12/18/07

Team Demos Safety of RNA Therapy 9/26/07

Mechanism For The In-Vivo Transport Of siRNA 9/17/07

RNAi Shows Promise In Gene Therapy, Stanford Researcher Says 2/18/07