Ambion Unveils New Technology Revolutionizing Small Nucleic Acid Purification

Austin, TX, April 25, 2005––Advancements in the field of small RNA research have driven Ambion scientists to develop a revolutionary electrophoresis device for the rapid, streamlined purification of small nucleic acids, such as siRNAs and microRNAs. Unlike traditional Polyacrylamide Gel Electrophoresis (PAGE), which was optimized for detection only, the innovative flashPAGE™ Fractionator System is designed for the purification of these small molecules. Using this system, scientists can save nearly an entire day of labor—enabling purification of small RNA and DNA molecules in approximately 12 minutes.

The flashPAGE technology has been rapidly embraced by leading molecular biologists. “With flashPAGE, we can quickly isolate small RNA molecules and do many more experiments in a day!” stated Andy Ellington, Professor at The University of Texas.

Ambion’s flashPAGE purification system uses an electrical current to drive nucleic acids through a proprietary denaturing gel matrix and buffer system, and into the lower buffer collection chamber. This chamber is designed for retention of eluted material, isolating highly purified nucleic acids for sensitive downstream investigation.

The need for more efficient small nucleic acid purification was Ambion’s driving force to reengineer decades old technology. According to David Brown, Ambion’s Associate Director of Research and Development, “We were faced with routinely gel-purifying both large and small amounts of siRNAs and miRNAs to facilitate our research.  To eliminate this mundane and inefficient process, we developed flashPAGE.  After experiencing the ease and efficiency of the flashPAGE process, we will never go back.”

Ambion, Inc., is a leader in the development and supply of innovative RNA-based life science research and molecular diagnostic products. As a market leader, Ambion also provides the widest range of products and services for small RNA applications, such as microRNA and RNA Interference. For more information, please visit www.ambion.com/prod/flashPAGE.